生物有机化学(第3版)(英文版)

　　It was over 100 years ago that Emil Fischer postulated his ingenious "lock-and-key" principle, which was subsequently applied to the development of a modern theory of enzyme catalysis. Later, the molecular recognition concept was used as the basis for the elaboration of the different fields of bioorganic chemistry. I am tempted to say that if Emil Fischer had lived in our time, he would undoubtedly be a leader in what is now called supramolecular chemistry, an important discipline of bioorganic chemistry. As we know, enzymes, by their complexity, set chemists a high standard for developing synthetic catalysts to imitate nature's highly selective enzymatic reactions. With the end of the twentieth century and the approach of a new millennium, bioorganic chemistry and enzyme mimetics are becoming more and more fashionable disciplines, particularly with the recent development and application of novel "molecular devices" that are expanding the frontiers of molecular science. With this point of view in mind, the third edition of the book was undertaken. ...
　　

series preface .
preface to the third edition
preface to the second edition
preface to the first edition
chapter 1 introduction to bioorganic chemistry
1.1 basic considerations
1.2 proximity effects in organic chemistry
1.3 molecular adaptation
1.4 molecular recognition and the supramolecular level
chapter 2 bioorganic chemistry of amino acids and polypepfides
2.1 chemistry of the living cells
2.2 analogy between organic reactions and biochemical transformations
2.3 chemistry of the peptide bond
2.4 nonribosomal peptide bond formation
2.5 asymmetric synthesis of a-amino acids
2.6 asymmetric synthesis with chiral organometallic catalysts
2.7 transition state analogs
2.8 antibodies as enzymes
2.9 chemical mutations
2.10 molecular recognition and drug design

　　It was over 100 years ago that Emil Fischer postulated his ingenious "lock-and-key" principle, which was subsequently applied to the development of a modern theory of enzyme catalysis. Later, the molecular recognition concept was used as the basis for the elaboration of the different fields of bioorganic chemistry. I am tempted to say that if Emil Fischer had lived in our time, he would undoubtedly be a leader in what is now called supramolecular chemistry, an important discipline of bioorganic chemistry. As we know, enzymes, by their complexity, set chemists a high standard for developing synthetic catalysts to imitate nature's highly selective enzymatic reactions. With the end of the twentieth century and the approach of a new millennium, bioorganic chemistry and enzyme mimetics are becoming more and more fashionable disciplines, particularly with the recent development and application of novel "molecular devices" that are expanding the frontiers of molecular science. With this point of view in mind, the third edition of the book was undertaken. .
　　The publication of this third edition also coincides with the 75th anniversary of the Department of Chemistry of the Universite de Montreal and my 25 years of teaching in this department.
　　To keep the book to a reasonable size, some sections from the second edition have been removed. Indeed, each chapter has been updated with new biomimetic examples, references, and/or review articles. At the same time, this exercise provided an opportunity to correct various graphic and typographic errors present in the previous edition. However, the major change in the third edition is a new chapter on molecular devices, in which the protocols of self-organization and self-assembly at the supramolecular level are exploited. Topologically complex molecules have until recently been regarded as mere academic curiosities, but their potential as components of molecular-scale devices is now being realized. Expressions such as molecular meccano and molecular tectonics or even molecular cybernetics are now used on a daily basis by a growing number of bioorganic chemists, and it is in these new domains, with an obvious analogy to molecular construction kits, that the fastest progress in bioorganic chemistry is taking place. ..
　　The reference section is composed of a list, although not exhaustive, of no less than one hundred review articles on bioorganic chemistry that appeared in the last 15 years. This impressive number is a strong barometer of the vivacity and growing popularity of the field.
　　Again, as in the previous editions, the emphasis is more on the concepts of bioorganic chemistry than on the details of synthetic and mechanistic difficulties of preparing the molecules within each individual project or field of application.
　　One of the goals of bioorganic chemistry is to mimic and understand via models the living processes in nature. This book is a tribute to this goal. However, the biomimetic approach is not limited to natural processes. Many biomodels go beyond the natural pathways and allow us to learn more about chemistry and nature, and often open new avenues in science. In this book I hope that I have succeeded, in a modest way, in transmitting this taste for knowledge. ...
　　Montreal, CanadaHermann Dugas
　　January 1995