基本信息
- 原书名：ESSENTIALS OF GLYCOBIOLOGY
- 作者： Ajit Varki Richard Cummings Jeffrey Esko Hudson Freeze
- 丛书名： 国外大学生物学优秀教材(影印版)
- 出版社：清华大学出版社
- ISBN：7302054878
- 上架时间：2007-1-22
- 出版日期：2002 年6月
- 开本：16开
- 页码：653
- 版次：1-1
- 所属分类：工业技术 > 化学工业 > 生物化工
内容简介
糖生物学是20世纪90年代才发展起来的生物化学中的最后的一个巨大学术前沿领域。糖生物学有着广阔的应用前景——它是生物化学和生物医学学科交叉的新前沿。.
国际著名糖生物学家美国加州大学Ajit Varki教授、Jeffrey Esko教授、 Jamey Marth教授以及美国霍普金斯医学院Gerald Hart教授等名校名家共同编写了这本《糖生物学》教材。他们以深厚的专业素养、广阔的学术视野、清晰的思路、优美的文笔，把一个蓬勃发展、精彩纷呈的学术领域呈现在读者面前，引领读者步入糖生物学的科学殿堂！..
本书适合高等院校生命学院、医学院及相关专业老师和学生以及从事糖生物学研究的研究人员阅读和参考。...
国际著名糖生物学家美国加州大学Ajit Varki教授、Jeffrey Esko教授、 Jamey Marth教授以及美国霍普金斯医学院Gerald Hart教授等名校名家共同编写了这本《糖生物学》教材。他们以深厚的专业素养、广阔的学术视野、清晰的思路、优美的文笔，把一个蓬勃发展、精彩纷呈的学术领域呈现在读者面前，引领读者步入糖生物学的科学殿堂！..
本书适合高等院校生命学院、医学院及相关专业老师和学生以及从事糖生物学研究的研究人员阅读和参考。...
目录
Foreword, vii.
Preface, ix
Contributors, xiii
Abbreviatioffs, xv
GENERAL PRINCIPLES.
1 Historical Background and Overview, 1
2 Saccharide Structure and Nomenclature, 17
3 Evolution of Glycan Diversity, 31
4 Protein-Glycan Interactions, 41
5 Exploring the Biological Roles of Glycans, 57
BIOSYNTHESIS, METABOLISM, AND FUNCTION
6 Monosaccharide Metabolism, 69
7 N-Glycans, 85
8 O-Glycans, 101
9 Glycosphingolipids, 115
10 Glycophospholipid Anchors, 131
11 Proteoglycans and Glycosaminoglycans, 145
12 Other Classes of Golgi-derived Glycans, 161
13 Nuclear and Cytoplasmic Glycosylation, 171
14 The O-GIcNAc Modification, 183
Preface, ix
Contributors, xiii
Abbreviatioffs, xv
GENERAL PRINCIPLES.
1 Historical Background and Overview, 1
2 Saccharide Structure and Nomenclature, 17
3 Evolution of Glycan Diversity, 31
4 Protein-Glycan Interactions, 41
5 Exploring the Biological Roles of Glycans, 57
BIOSYNTHESIS, METABOLISM, AND FUNCTION
6 Monosaccharide Metabolism, 69
7 N-Glycans, 85
8 O-Glycans, 101
9 Glycosphingolipids, 115
10 Glycophospholipid Anchors, 131
11 Proteoglycans and Glycosaminoglycans, 145
12 Other Classes of Golgi-derived Glycans, 161
13 Nuclear and Cytoplasmic Glycosylation, 171
14 The O-GIcNAc Modification, 183
前言
THE ESSENTIALS OF GLYCOBIOLOGY could not appear at a more opportune time, for the field is in a period of enormous progress and the prospects for future advances are even greater. Glycobiology has its roots in the nineteenth century, when chemists first began to analyze sugars and polysaccharides. Perhaps the first glycoprotein to be studied was the "glycogenous matter" of liver which the famous French physiologist Claude Bernard identified in 1855 as a storage form of glucose. (Interestingly, the evidence that glycogen is a glycoprotein was not obtained until more than 100 years later.) Advances in this area continued at a steady rate during most of this century, but the past 20 years has witnessed an unparalleled explosion of new knowledge that has transformed the field. There are many reasons for this acceleration of progress, induding great technical advances in establishing oligosaccharide structures, but by far the most important is the application of recombinant DNA technology to the field. This has resulted in the molecular characterization of the enzymes involved in the assembly, processing, and degradation of oligosaccharides and proteoglycans. It has also allowed the identification of numerous families of plant and animal lectins that recognize carbohydrate structures. The surprising finding to emerge is the vast number of enzymes and proteins that are devoted to glycoprotein and glycolipid synthesis and function. The understanding of the biologic roles of glycans has also increased to a great extent, and we now know that these molecules serve multiple functions, ranging from assisting the folding of nascent proteins to determining the trafficking of lymphocytes and granulocytes in the circulation. The important role of glycans is underscored by the growing list of human diseases that are the result of defects in glycan assembly. The challenge for the future is to further define the biologic functions played by glycans. In this regard, recombinant DNA technology has provided another valuable tool for the glycobiologist: the ability to disrupt genes of interest in mice and other organisms. This presents an unparalleled opportunity for the scientist interested in elucidating the biologic roles of sugars. Without a doubt, the future in this area is the brightest it has ever been..
Essentials of Glycobiology provides an ideal entry into the field. It contains the basic information needed to understand this area along with the most current work at the forefront of the field. The authors are to be commended for assembling a broad, comprehensive, well-organized overview of this burgeoning field. They have also been successful in conveying the excitement in this area of research...
Stuart Kornfeld
Washington University School of Medicine
March 1999...
Essentials of Glycobiology provides an ideal entry into the field. It contains the basic information needed to understand this area along with the most current work at the forefront of the field. The authors are to be commended for assembling a broad, comprehensive, well-organized overview of this burgeoning field. They have also been successful in conveying the excitement in this area of research...
Stuart Kornfeld
Washington University School of Medicine
March 1999...
序言
EMERGING FROM ITS ROOTS in classical carbohydrate chemistry and biochemistry, glycobiology has become a vibrant, expanding, and important extension of modern molecular biology. Over the years, many outstanding monographs and books have documented important advances in this area and summarized critical methods and concepts (see listing following this preface). These volumes continue to serve as excellent resources for those interested in glycobiology. Why then should one publish an additional book on the subject? Most of these prior volumes have been directed at the specialist, assuming a substantial level of technical sophistication and expertise and a working knowledge of the relevant jargon. We present here a book that seeks to fulfill a somewhat different need: to summarize the current state of the art for the expert and yet serve as a resource for the novice wishing to explore the essentials of glycobiology..
This book had its origins from some independent lines of effort. For several years, some of us have been teaching a short elective course in glycobiology for graduate students at the University of California, San Diego. With the recent arrival of additional faculty with expertise in this field, it was decided to present a more comprehensive course on the subject, to be supplemented by a course book that could be then converted into a formal text. Meanwhile, other experts elsewhere in the country had put forward independent proposals to fill the perceived need for a basic textbook in glycobiology. Following a discussion over a beer after a glycobiology conference, we decided to pool all our efforts in this direction...
Since a major goal was to produce a text that would be accessible to students and other trainees, we used the 1998 UCSD Spring Quarter Graduate Course in Glycobiology as the basis for creating the text. By recruiting several additional experts as lecturers, we could present a comprehensive course that covered most aspects of the field. Each lecturer was asked to provide handouts for the students that were essentially the first drafts of chapters for the book. In turn, each student was required to provide anonymous critiques of some chapters as a part of the course requirement. This approach ensured not only that the draft chapters were written early on, but also that they underwent in-depth evaluation by bright young minds with an expressed interest in the field. Additional rounds of internal review by the group of six editors served to produce what we hope will be a valuable resource not only for the expert in the field, but also for the novice who wants to learn about glycobiology. We have tried to be as accurate and up to date as possible and to present a balanced point of view on controversial subjects. Given the current breadth of knowledge, it was not possible to do full justice to all aspects of the field, nor to comprehensively reference the extensive literature that exists. The relative emphasis on vertebrate biology bespeaks the greater volume of information currently available in this area of glycobiology.
The Editors are indebted to many others who made this book possible. Besides the students who took the course for credit, several other trainees audited the course and provided very useful feedback. Although the editors wrote the majority of the chapters in the book, the efforts of the other lecturer/authors were crucial in assuring the depth of expertise needed to cover the field effectively. Special thanks are due to John Inglis and Kaaren Janssen at Cold Spring Harbor Laboratory Press for realizing the potential of this book, and for putting up with our many demands and idiosyncrasies. We also thank the Press staff, Jan Argentine, Inez Sialiano, Mary Cozza, Denise Weiss, Dotty Brown, and Danny deBruin, who deserve much credit for keeping us on track and converting our efforts into an attractive product. Last but not least, we acknowledge our families, lab members, and administrative assistants who supported us through all of the hard work needed to create this text. It now remains for the reader to decide if we have achieved our goals in producing this book....
Ajit Varld
for
The Editors
This book had its origins from some independent lines of effort. For several years, some of us have been teaching a short elective course in glycobiology for graduate students at the University of California, San Diego. With the recent arrival of additional faculty with expertise in this field, it was decided to present a more comprehensive course on the subject, to be supplemented by a course book that could be then converted into a formal text. Meanwhile, other experts elsewhere in the country had put forward independent proposals to fill the perceived need for a basic textbook in glycobiology. Following a discussion over a beer after a glycobiology conference, we decided to pool all our efforts in this direction...
Since a major goal was to produce a text that would be accessible to students and other trainees, we used the 1998 UCSD Spring Quarter Graduate Course in Glycobiology as the basis for creating the text. By recruiting several additional experts as lecturers, we could present a comprehensive course that covered most aspects of the field. Each lecturer was asked to provide handouts for the students that were essentially the first drafts of chapters for the book. In turn, each student was required to provide anonymous critiques of some chapters as a part of the course requirement. This approach ensured not only that the draft chapters were written early on, but also that they underwent in-depth evaluation by bright young minds with an expressed interest in the field. Additional rounds of internal review by the group of six editors served to produce what we hope will be a valuable resource not only for the expert in the field, but also for the novice who wants to learn about glycobiology. We have tried to be as accurate and up to date as possible and to present a balanced point of view on controversial subjects. Given the current breadth of knowledge, it was not possible to do full justice to all aspects of the field, nor to comprehensively reference the extensive literature that exists. The relative emphasis on vertebrate biology bespeaks the greater volume of information currently available in this area of glycobiology.
The Editors are indebted to many others who made this book possible. Besides the students who took the course for credit, several other trainees audited the course and provided very useful feedback. Although the editors wrote the majority of the chapters in the book, the efforts of the other lecturer/authors were crucial in assuring the depth of expertise needed to cover the field effectively. Special thanks are due to John Inglis and Kaaren Janssen at Cold Spring Harbor Laboratory Press for realizing the potential of this book, and for putting up with our many demands and idiosyncrasies. We also thank the Press staff, Jan Argentine, Inez Sialiano, Mary Cozza, Denise Weiss, Dotty Brown, and Danny deBruin, who deserve much credit for keeping us on track and converting our efforts into an attractive product. Last but not least, we acknowledge our families, lab members, and administrative assistants who supported us through all of the hard work needed to create this text. It now remains for the reader to decide if we have achieved our goals in producing this book....
Ajit Varld
for
The Editors
